Not filling it more, but experiencing better skin.

Celivion

Cellivion Lindsay, a next-generation skin reviser that helps with flawless anti-aging through direct ECM replenishment
Cellivion, a next-generation ECM skin reviser derived from acellular allogeneic dermis (hADM), goes beyond temporary plumping to fundamentally restore damaged internal structures, reviving your natural beauty.
Improvement of fine lines around the eyes
Improvement of nasolabial folds
Improved skin texture
Volume maintenance and supplementation
Improves skin radiance and hydration
neck wrinkle improvement

As aging progresses, the ECM environment that supports the skin also changes.

These changes lead to changes in the overall skin condition, such as elasticity, density, and texture.
AGING SKIN
• Decreased fibroblast activity • Decreased ECM density • Increased space between fibers
HEALTHY SKIN
• Active fibroblast • Dense collagen/elastin network • Dense ECM environment

What is ECM, which supports the skin's structure?

The ECM is an aggregate of dermal components that fill the space around skin cells and support the structure of skin tissue.
ECM - The structural environment that makes up the skin
Collagen: Structural support of skin tissue
ELASTIN is involved in skin elasticity and flexibility.
GAGs are involved in maintaining the skin's moisture environment.
OTHER ECM: Various components such as Fibronectin and Laminin

What if there were only rebar and no cement? 'ECM', the binder inside the skin

If collagen and elastin are the sturdy 'rebar framework,' then the cement paste that fills the gaps between them and hardens them is the ECM (Extracellular Matrix).
If you have these skin concerns, consider Cellivion.
I am worried about fine lines.
I am worried about loss of skin elasticity.
I am worried about enlarged pores.
I am worried about my rough skin texture.
I want to improve my skin tone
I am looking for an allogeneic dermal collagen-based procedure.
I want natural skin condition improvement

Temporary induction of active signals vs. direct replenishment of real dermal components

The difference lies in a next-generation mechanism that moves beyond stimulating aging collagen factories to directly and completely replenish the essential components needed for the damaged dermis layer of the skin!
Why is it called Human-derived hADM?
hADM, derived from human skin, supports skin tissue regeneration and natural tissue fusion based on its high biocompatibility.
Contributes to the improvement of overall skin condition, such as texture and elasticity.

High biocompatibility

High biocompatibility

Supports skin tissue regeneration

Provides a structural foundation for skin regeneration

Support for fibroblast activation

Creates a regenerative environment by promoting fibroblast activity

What are fibroblasts? They are key cells that aid in wound healing by synthesizing the extracellular matrix (ECM), such as collagen and elastin.

Natural tissue fusion

Naturally blends with surrounding skin tissue

High-concentration allogeneic collagen

Containing a high concentration of allogeneic collagen, it maximizes its function as a scaffold necessary for tissue regeneration and reconstruction.
The rich collagen content provides a denser scaffold to damaged tissue sites and contributes to creating a stable regenerative environment for cell adhesion and tissue integration.
WHY CELIVION
Cellivion approaches the issue with human skin-derived ECM materials

The choice for the next skin, the next-generation ECM skin reviser Cellivion Lindsay

Based on human-derived ECM, from the preservation of the ECM structure to particle design and safety verification

Cellivion is a product that focuses not on how much collagen is added, but on how much 'living structure' is included.

hADM benefits

Biocompatibility and Safety
Allogeneic collagen has a structure similar to human skin tissue, so it is less likely to cause immune reactions or side effects.
Induces natural skin regeneration
Allogeneic collagen promotes skin tissue regeneration by providing a structural basis for the production of new collagen. In particular, it possesses high retention power due to the activation of fibroblasts and skin tissue fusion effects.
Natural texture and absorbency
Allogeneic collagen is naturally absorbed deep into the skin, leaving a soft texture and high satisfaction.

Excellence and Safety of hADM

The excellence of hADM

Naturally derived
Derived from human collagen, it has high skin affinity and is absorbed into the body to stimulate collagen production.
Playback effect
Long-term effects are expected as it induces the improvement of the skin's foundation rather than simply adding volume.
Improvement effect
It helps improve not only wrinkles but also overall skin condition, including texture, pigmentation, and elasticity.

Safety of hADM

No allergy risk
There is a low risk of immune response due to autologous or human-derived ingredients.
No foreign body sensation
It is naturally absorbed over time after injection, so there is no foreign body sensation.
Minimizing serious side effects
Allogeneic collagen is naturally absorbed, so the risk is low.

It is difficult to consider the quality of all human-derived ECM materials to be the same simply because hADM is used.

Check the quality of Celivion hADM.

Point 1 ECM PRESERVATION
Are the ECM structure and key components well preserved even after processing?
We check how intact the original structures of collagen and ECM are maintained during the processing.
Minimizes damage to the ECM structure through a low-temperature process.
ADM undergoes a decellularization process that removes cellular components from human skin tissue. During this process, it is crucial to manage processing conditions to ensure that unnecessary cellular components are sufficiently removed while preventing excessive damage to the dermis's inherent collagen and ECM structures. CELIVION LinJ is designed to minimize damage to the biological structure of the ECM by applying Allo-PELT™, a proprietary low-temperature circulation-based decellularization processing technology.

HUMAN-DERIVED SKIN

raw materials
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DECELLULARIZATION

Removal of cellular components
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Low-Temperature Process

Allo-PELT™
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Preserved ECM

ECM structural preservation
After the low-temperature process, the structure and components of the ECM were verified.
We confirmed the ECM preservation status of the product to which low-temperature processing was applied through structural observation and component analysis.
01. Verification of ECM Microstructure
In CELIVION LinJ, the characteristic grain of collagen was maintained relatively clearly and parallelly, and a form in which each layer was arranged in a consistent manner was observed.
02. Quantitative Analysis of ECM Components
Point 2 PARTICLE CONTROL
Are the size and distribution of ECM particles precisely designed?
Verify that it has a size suitable for the procedure and a uniform particle size distribution.
Processes the preserved ECM into fine microparticles.
When processing hADM into injectable fine particles, it is crucial not only to reduce the particle size but also to consistently manage particle size and distribution. CELIVION LinJ utilizes an ultra-precision grinding process and ECM Mix Cage™ to manage particle size characteristics, ensuring that particles are distributed within a consistent range rather than being concentrated in specific sizes.

Preserved ECM

Preserved ECM
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PRECISION MICRONIZATION

Miniaturization
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ECM Mix Cage™

Particle size control
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CONTROLLED PARTICLES

uniform distribution
Particle size and distribution were confirmed through particle size analysis.
We check not only whether the particles are simply small, but also whether they are distributed within a certain range without being excessively biased toward a specific size.
Check the particle size of the collagen!
Check the uniformity of the collagen particles!
Point 3 SAFETY VERIFICATION
Has its safety been objectively verified as a human-derived material?
As it is a human-derived material, decellularization, biocompatibility, and donor safety are verified through objective testing.
Human-derived materials require verification from the selection of raw materials to safety confirmation.
CELIVION LinJ confirms safety through tests regarding donor management, degree of decellularization, cytotoxicity, and process residues.
40 ng/mg
Residual DNA
Remaining DNA levels after decellularization: 50 ng/mg or less
94.8%
Cell Viability
Cell viability confirmed in cytotoxicity tests
NOT DETECTED
Surfactant Residue
Surfactant residue test: not detected
10 Tests
including HBV-NAT
Serological tests based on AATB management standards